Sentence examples for distal changes from inspiring English sources

Thus unlike VEGF in the previous subsection, interstitial sVEGFR1 (e.g., [sR1]IS,Calf) was able to respond to distal changes (e.g., qsR1,Normal).

Distal changes affect disease only through a series of causal linkages.

The distal changes are larger in temporal and spatial scales than the more proximal environmental characteristics that they influence.

Figure 5 and the top panel of Figure 7 show distal changes in backbone and side-chain flexibility, respectively, at functional sites of the PPIase domain.

Interestingly, subtle and distal changes due to protein circular permutation can profoundly alter the proton transfer kinetics while still qualitatively fitting within the coupled two-site framework.

Application of these models resulted in identification of the piperidine ring as a likely site for chain derivatization with preservation of affinity, and a series of analogues was synthesized to probe the effect of distal changes on antagonist potency.

The list of distal environmental changes in Table 1 includes anthropogenic changes that affect landscape ecology, human ecology, and human-created environments as well as natural perturbations and natural disasters.

This is consistent with previous observations of ligand binding-induced distal conformational changes on DHFR.

In FM there are distal vasomotor changes manifested as pseudo-Raynaud phenomenon [ 16] and soft tissue swelling.

We show that substrate and especially phosphorylated substrate binding at the ABS induce distal conformational changes at the catalytic site, toward an activated state of GSK-3β(p).

We choose to disaggregate the environment into distal environmental changes that act on disease transmission through multiple intermediate steps and proximal environmental characteristics that directly affect disease transmission.