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Firstly the dissolved oxygen control loop was identified.
A future challenge is the optimization of this bioprocess by improving the dissolved oxygen control strategy and reactor design.
The paper includes simulation results for the case of a dissolved oxygen control loop in an activated sludge wastewater treatment plant.
Two control loops were implemented: one for dissolved oxygen control using the oxygen transfer coefficient KLa as manipulated variable, the second one for nitrate control in the anoxic zone using the internal recirculation flow rate as manipulated variable.
Dissolved oxygen control strategy for enhancing TL1-1 production was first proposed.
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The production bioreactor was operated in fed-batch mode, with agitation, pressure, temperature, pH and dissolved oxygen controlled.
The seed train bioreactors were operated in batch mode, with agitation, pressure, temperature, pH and dissolved oxygen controlled during the process.
The QFT robust control method has been chosen for the dissolved oxygen concentration control.
Experimental results demonstrate that the proposed controller can achieve high performance on dissolved oxygen level control in WWTP.
Parameters evaluated include agitation rate, pH and dissolved oxygen (DO) control set-points, and media formulation.
In this study, to enhance GlcNAc production, glucose feeding approaches and dissolved oxygen (DO) control methods in fed-batch culture were systematically investigated.
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