Exact(8)
The ODMA monomer acts as a physical crosslinker, preventing polymer dissolution upon temperature reduction.
Conventional immediate release dosage forms involve compressing the powder with a disintegrating agent that enables rapid disintegration and dissolution upon oral ingestion.
In Application I, an experimental design was carried out to evaluate the interactions and effects of the design factors on critical quality attribute (CQA) of dissolution upon stability.
In Application II, an experiment was conducted to study the impact of varying tablet breaking force on dissolution upon stability utilizing MPCA.
It was demonstrated that the use of multivariate methods, defined as Quality by Design (QbD) principles and tools in ICH-Q8 guidance, provides an effective means to achieve a greater understanding of tablet dissolution upon stability.
To assess the consequences of disruption of the intact axis in the MARY-X spheroids, dissolution upon Ca++ depletion was performed.
Similar(52)
Multivariate techniques, such as multi-way principal component analysis (MPCA) of the entire dissolution profiles upon stability, were performed to reveal batch relationships and to evaluate the impact of design factors on dissolution.
The process of drug dissolution depends upon a number of physical phenomenon i.e. wetting of the particle's surface, breakdown of solid state bonds, solvation, diffusion (through the liquid unstirred boundary layer surrounding the particle), and convection.
This drawback of chemical etching was compensated for by the discovery of metal-assisted etching which utilizes noble metal deposits on Si in order to increase its dissolution rate upon etching in a mixture of HF and an oxidative agent [9].
This feature was employed to achieve (1) a more even distribution of acid functionalities throughout the growing polymer chains and the corresponding latex particles, (2) improved dissolution behavior upon deprotonation of the acid groups and (3) the possibility to tailor rheological properties at elevated pH values.
This acid is a potent erosive agent, because it has the ability to chelate calcium, increasing dental enamel dissolution rates upon the acid challenges that are imposed.
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