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Dissolution analysis was performed using the Pharma Test PT 017 dissolution apparatus (Pharma Test Group, Pharma Test, Hainburg, Germany).
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Dissolution data analysis is performed by comparing dissolution profiles statistically or using mathematical models to quantify or characterize the drug release from a pharmaceutical dose form.
A dissolution method with high performance liquid chromatography (HPLC) analysis was validated for an immediate release low dose tablet formulation.
An ANOVA analysis was done to compare the differences of the dissolution profile of the three different formulations with different excipients.
Then selective dissolution method and thermal analysis were used to quantitatively analyze the content of FA in hardened paste.
Dissolution tests and high performance liquid chromatography analysis were conducted.
Quantitative analysis is performed and a linear dependence of platinum dissolution with chloride concentration is observed.
This way, together with in vitro dissolution analysis, in vivo bioavailability studies are critical to obtain a formulation with the desired pharmacokinetic and toxicity profiles.
Quality of amodiaquine drugs was relatively better but still unacceptable as 7.5% did not comply within the tolerance limits of the dissolution analysis.
The observed kinetics reveal that the dissolution rate increases substantially with progressing dissolution, suggesting that dissolution is an auto-catalytic process.
17 The amount of stated API for the content analysis and release over time for the in vitro dissolution testing was measured using HPLC-PDA, following USP monographs.
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