Of 37 samples (chloroquine N = 25; sulfadoxine/pyrimethamine N = 9; quinine N = 3) tested using the dissolution analysis to determine the quality of the formulations, 12 (32%; N = 9 sulfadoxine/pyrimethamine and quinine N = 3) did not meet the set USP tolerance limits and were therefore of poor quality.
Dissolution analysis involves a comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern.
Quality of amodiaquine drugs was relatively better but still unacceptable as 7.5% did not comply within the tolerance limits of the dissolution analysis.
Dissolution analysis was performed using the Pharma Test PT 017 dissolution apparatus (Pharma Test Group, Pharma Test, Hainburg, Germany).
Thus, in [12], where Se thin films with PbSe nanoclusters were fabricated electrochemically in nitric acid-based solutions via anodic dissolution of PbSe, the analysis of the corresponding processes showed the reaction of PbSe dissolution to Pb2+ ions and Se atoms, which presumably takes place for the porous layers as well.
On the basis of the theoretical data sets, it was demonstrated that the introduced analysis of dissolution profiles correctly identifies the disintegration rate of FDF containing multiple particle types.
This report focuses on the analysis of dissolution data to evaluate the application of the DDSolver program to two dissolution studies: (1) the comparison of dissolution profiles between different products, (2) fitting of drug release data to the K-P model and its modifications.
For accurate analysis, the analyte needs to be soluble in the mobile phases, hence for analysis of dissolution samples, standard samples of ciprofloxacin and diclofenac sodium were dissolved in water and acetonitrile at a ratio of 1 : 1, which was completely miscible with the mobile phases over the three minutes run time.
22 A subset of 40 samples were analyzed by in vitro dissolution methods and content analysis of the API by high-performance liquid chromatography with ultraviolet diode array detection (HPLC-UV-PDA) following previously described standard operating procedures (SOPs) used to determine the quality of drugs.
We also present a sensitivity analysis of the dissolution process with respect to acid injection rate, dissolution rate constant and rock properties such as initial average permeability, heterogeneity and permeability porosity relationships.
