(D ) Schematic of all possible 'double-dissociation' scenarios used for establishing bootstrap significance levels of the actual result.
In such a scenario, dissociation would be associated with different characteristics of inner speech, and these in turn would lead to greater hallucination-proneness.
The study also allows us to explore the nonspecific binding landscape near the binding site and reveals that, rather than a two-state bound/unbound scenario, drug dissociation entails shuttling between many metastable local minima in the free-energy landscape.
In such a scenario, the high dissociation constant of the cytochrome c-neuroglobin complex allows more frequent association of cytochrome c with Apaf-1, resulting in increased chances of apoptosome formation and thus increased apoptosis (compare Figs. 3c, 5b).
For each of the two dissociation variants, we therefore considered two scenarios: In the first, we assume that this control does not exist by setting u' = 1.
Calculations indicate that H-abstraction of the aliphatic proton of DONA by a hydroxyl radical is the thermodynamically favored reaction path in oxidative media, whereas hydrolysis is not a realistic scenario due to the high dissociation constant.
We next illustrate this dissociation by considering the even more extreme scenario where the two measures go in opposite directions.
Reviewer #2: 1) The authors show that "energy consumption can indeed decrease the dissociation constant... with respect to an equilibrium scenario".
Major comments: 1) Question concerning novelty: The authors show that "energy consumption can indeed decrease the dissociation constant... with respect to an equilibrium scenario".
For both, the Dissociation and the Convey variants, we compare two different scenarios concerning the microtubule attachment dependent control of the dissociation reaction.
