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Thus their occurrence in dissimilar domain contexts, provided homology can be detected by sequence or structural similarity, forms the basis of evolutionary domain definition.
The test set is defined as the set of the domains, where GOTOH scores a dissimilar domain (neither in the same SCOP fold nor in the same CATH architecture) better than a domain from its own SCOP family and CATH superfamily.
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Most of the intertwined dimers form closed assemblies with head-to-tail arrangements, where the subunit interface involves contacts between dissimilar domains.
Blockbuster's experience shows that executing a bricks-and-clicks strategy entails a high degree of difficulty, managing not just two very different kinds of businesses, with dissimilar domains of expertise, but also a third challenge: integrating two separate systems.
Rosenstein et al. [8] demonstrated this by showing how transferring between dissimilar domains causes performance loss.
Many domains have different functions in different proteins, especially when in combination with other dissimilar domains.
SCOP unifies these proteins in one class as they contain topologically dissimilar domains (e.g. all-alpha, all-beta, alpha/beta and alpha+beta) closely associated with each other, both structurally and functionally.
In this article, we analyzed vignettes in two distinct and dissimilar domains of physical and mental health viz.
Taking into account the overlap in the domains that are presented in these questionnaires, the number of dissimilar domains represented across the questionnaires is 30.
BCL-2 family-derived pore-forming helices thus represent structurally analogous, but functionally dissimilar membrane domains.
Families such as the kinesin/myosin motor domains contain dissimilar sub-groups such that domains within a sub-group are aligned with much higher accuracy than domains from different sub-groups.
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