Your English writing platform
Discover LudwigExact(1)
Because it is meaningless to compute the periodicity between two dissimilar actions, we choose to empty the matrix S when a motion cycle is detected in order to avoid computing the self-similarity between two dissimilar actions.
Similar(59)
Often, dissimilarity was inferred on the basis of diverse chemical structures, but proof of dissimilar action could not be provided because the actual mechanisms involved were unclear.
Whether the CA and IA can predict mixture toxicity of phenolic compounds with similar and dissimilar action mechanisms was studied.
Therefore, it can be concluded that both CA and IA can predict reliable results for the mixture toxicity of the phenolic compounds with similar and dissimilar action mechanisms.
Many of these models are based on the work of pioneers in mixture toxicology who defined three basic types of action for combinations of chemicals: simple similar action, simple dissimilar action and interaction.
Thus, there is a need to consider studies that have employed very strict criteria for dissimilar action.
Such dichotomous approaches are problematic, for several reasons: First, unambiguous criteria for what should constitute "similar" or "dissimilar" action do not exist and are currently difficult to define.
In view of the diversity of "real world" mixtures composed of numerous different chemicals with a multitude of different modes of action, it is suggestive to regard dissimilar action of mixture components as the default scenario.
For the two binary mixtures (Mixtures IV and V), composed with the intention of realising the principles of dissimilar action, IA did prove to be a reasonable approach for approximating the experimentally observed effects.
Other studies have demonstrated that MN induced by binary mixtures of two methylating agents (similar action) could be predicted by CA, whereas binary mixtures with methylating agents and topoisomerase inhibitors (dissimilar action) led to effects that fell between the CA and IA prediction in one case and were smaller than anticipated by IA in another case (Lutz et al. 2005).
In addition, we observe that the spatial-temporal features of trajectories are similar in the same kind of action, whereas those between different actions are dissimilar.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com