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Often, dissimilarity was inferred on the basis of diverse chemical structures, but proof of dissimilar action could not be provided because the actual mechanisms involved were unclear.
Whether the CA and IA can predict mixture toxicity of phenolic compounds with similar and dissimilar action mechanisms was studied.
Therefore, it can be concluded that both CA and IA can predict reliable results for the mixture toxicity of the phenolic compounds with similar and dissimilar action mechanisms.
Many of these models are based on the work of pioneers in mixture toxicology who defined three basic types of action for combinations of chemicals: simple similar action, simple dissimilar action and interaction.
Thus, there is a need to consider studies that have employed very strict criteria for dissimilar action.
Such dichotomous approaches are problematic, for several reasons: First, unambiguous criteria for what should constitute "similar" or "dissimilar" action do not exist and are currently difficult to define.
Similar(51)
Because it is meaningless to compute the periodicity between two dissimilar actions, we choose to empty the matrix S when a motion cycle is detected in order to avoid computing the self-similarity between two dissimilar actions.
In addition, we observe that the spatial-temporal features of trajectories are similar in the same kind of action, whereas those between different actions are dissimilar.
The classification of similar and dissimilar modes of action as applied in the present study relates to the pesticidal mode of action of the a.s., hence to the specific toxicity towards the target organisms based on the known molecular target and the development of cross-resistances in target organisms.
The web tests of drugs indicated that while two drugs may produce near-identical behaviors in higher animals, their dissimilar mechanisms of action result in different disruptions in web construction.
These dissimilar mechanisms of action may be related to the differences in lipid and protein content between the cellular plasma membranes or to the manner in which DNA and RNA is protected within the cell models we used.
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