This may be associated with potential route of dissemination, given that cells could distribute from a primary tumour through lymphatic or blood vessels, whereas tail-vein injection forces dissemination through the latter route.
Our results show that caspase 3 activation in early stages of the infection, was relevant for virus exit and that membrane blebbing contributes to virus dissemination, given the fact that the inhibition of the effector caspase 3 reduced the release of virus particles from the cell and this effect was enhanced when the inhibitor was added after 6 hpi.
It has been proposed that subpopulations of CTCs with tumor-initiating potential act as a central mediator of metastatic dissemination, giving rise to the formation of distant micrometastases, which subsequently generate overt detectable and frequently measurable lesions [ 6].
The researchers believed that the involvement of all stakeholders throughout research planning and design, conduct of research and result dissemination gave them ownership of the research and thus increased the likelihood of policy adaptation and implementation.
Similarly, NLCQ-1 was unable to reduce metastatic dissemination when given pre-radiotherapy (data not shown).
Some examples of criteria for measuring appropriate dissemination are given in table 4 Definitions of capacity building suggest that it should contain elements of sustainability which alludes to the maintenance and continuity of newly acquired skills and structures to undertake research [ 18, 19].
Are there, in fact, ways to improve dissemination of funds, given the need to keep funding processes clear, transparent and secure?
Missing data were handled as follows: missing fifth of neighbourhood income relates to the instability of the population in any given dissemination area (for instance, areas with high numbers of university students) and as such this category was kept separate and those patients were included.
The fact that our research was not initially intended to draw a reflection on HTA in general, but to describe, in a short time and for internal purposes only, emerging practices of knowledge production and dissemination at a given HTA agency constitutes a limit.
In reality, only a small minority of tumor cells in the primary tumor is actually motile and capable of invasion and dissemination at any given time, as has been visualized in mouse and rat mammary tumor models with intravital multiphoton microscopy [ 8, 9].
Indeed, the most challenging issue in geocast protocols is the definition of the ZOR for a given event dissemination.
