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Ichinose et al (1997) reported that intraoperative intrapleural treatment using hypotonic cisplatin solution (cisplatin solution diluted by distilled water) effectively controlled malignant pleural effusion and/or pleural dissemination found at thoracotomy in NSCLC patients.
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In a quarter of patients with AT/RT, leptomeningeal dissemination is found at the time of presentation [37, 39, 40].
A small clonal dissemination was found, which accounted for 12 PFGE type H isolates.
In our patients no clinical evidence of distant dissemination was found preoperatively.
Interestingly, none of the patients with leptomeningeal dissemination were found to have ALT phenotype.
Examples of successes and failures of information dissemination are found in the results of research on silicosis.
Definitions used for case - inclusion [ 5]: - Dissemination: larvae found in any organ, other than the respiratory and the gastrointestinal tracts.
Pleural dissemination was found in six patients, and distant lymph node metastases involving, for example, the para-aortic, axial, and inguinal lymph nodes, were identified in ten patients.
A neutropenic murine model of P aeruginosa gastrointestinal colonisation and dissemination also found that strains expressing ExoU were more virulent than strains lacking it.
Patients with EM had significantly deeper tumor invasion and larger number of lymph node metastases; in addition, peritoneal dissemination was found more frequently at surgery in patients with EM (Table 1).
In a prospective study in patients whose malignant pleural effusion and/or pleural dissemination were found at thoracotomy, intraoperative intrapleural HPT for 15 min before the closure of thorax prolonged the control of the pleural disease (Ichinose et al, 1997).
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