Despite the aggressive nature of melanoma and the potential for early disease dissemination, extensive imaging (e.g. CT of the chest, abdomen, pelvis and brain) of asymptomatic patients with stage I or II melanoma is usually not indicated, since the detection rate is low and the frequency of false-positive findings is unacceptably high (10 20%) [ 25, 28, 47].
There is a predilection for rapid dissemination and extensive involvement, including extrathoracic nodes, bone marrow, central nervous system and gonads.
Survival and replication in macrophages, eventually followed by macrophage pyroptosis, is fundamental to allowing dissemination and extensive colonization of the intestinal epithelium (Ashida et al., 2011).
The suggestion that the criminal law should only apply in circumstances where there has been extensive dissemination in other words where there are a significant number of Twitter followers involved, is in direct contrast to the basic principles of our libel laws, which only require a meaningful extent of publication for a defamatory allegation to be actionable.
In the former setting, the disseminated disease is often clinically limited due to postoperative adhesions, whereas in the latter setting, dissemination is generally extensive.
Its aggressiveness and extensive dissemination lead to poor patient prognosis.
Despite the extensive dissemination of cactus species around the world, only a small proportion of the family is currently known to be invasive.
Therefore, there is evidence that CRKP isolates have undergone extensive dissemination in many countries and continue to spread in new geographical locations.
It is likely that high FilGAP expression causes establishment and maintenance of amoeboid features in lymphoma cells, which induce adaptation of their shapes to squeeze through pores in the extracellular matrix, resulting in the accelerated progression and the extensive dissemination.
There has been an extensive dissemination of 'good palliative care practice' guidance for example, the Gold Standards Framework (GSF) [ 20], and care pathways for the final days of life, such as the Liverpool Care Pathway for the Dying Patient (LCP).
The extensive dissemination of E. coli in the community [ 37] and its subsequent spread in hospitals illustrates the importance of movement of patients between the community and the healthcare system, in particular between nursing homes and acute hospitals.
