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Based on the scenarios, the existing literature, and the authors' experience, dissemination challenges that researchers and practitioners may experience (i.e., issues of design, measures of outcomes and external validity, the balance between fidelity and adaptation to local settings, and the review and funding of dissemination science) are discussed.
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These observations provide evidence of the crucial role of NK-DC cross-talk in promoting viral dissemination, and challenges the question of the in vivo involvement of HMGB1 in the triggering of viral replication and replenishment of viral reservoirs.
These observations provide evidence for the crucial role of NK-DC cross-talk in promoting viral dissemination, and challenge the question of the in vivo involvement of HMGB1 in the triggering of HIV-1 replication and replenishment of viral reservoirs in AIDS.
The provisioning of context-aware services also depends on the seamless integration of data collection, processing and dissemination systems whose challenges we have discussed in the earlier sections.
Although evidence-based prevention programs exist, successful adaptation to provide wide dissemination presents a challenge.
Measuring the effectiveness of these vital spread and dissemination activities is challenging.
Pertinent to the current studies is a previous investigation that examined the effect of influenza A virus infection on meningococcal dissemination using virally challenged mice (Alonso et al., 2003).
Despite clear scientific evidence on efficacy of these innovations, initial efforts to promote these technologies have run into challenges surrounding diffusion, dissemination, and implementation.
The difficulty of early diagnosis and the rapid dissemination represent outstanding clinical challenges associated with EOC and contribute to the frequent failure of current treatment protocols.
Reasons may include: a lack of evidence to base information on and the need to update resources according to the latest evidence; challenges with dissemination (e.g. translating evidence into readily accessible and understandable resources); and barriers to implementation (e.g. enlisting the support of organizations and clinicians).
The taskforce has met six times since June to examine ways to challenge the dissemination of extremist views in schools, colleges, charities, Islamic centres and prisons.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com