The recruitment of CCR1+ neutrophils in early phase of colon cancer dissemination appears to cause that of fibrocytes in late phase.
This clustered cohort-like cancer cell dissemination appears to be highly efficient in embolizing lymphatic or blood vessels and in cell survival in the circulation 11, 62. Collective cell migration is mainly seen for basal cell carcinomas and squamous cell carcinomas of various origins.
Intrathecal chemotherapy administered via an Ommaya reservoir was incorporated as a method of preventing or treating leptomeningeal dissemination, and appears to be beneficial for patients who receive focal irradiation only.
Dissemination might appear in a late phase of tumorigenesis when a primary tumor achieves a critical mass of cells and gains a highly aggressive phenotype (linear model) or it might be initiated much earlier, even when a malignant tumor is still of small size (parallel model) [ 14].
Alternatively, since tumour dissemination often appears to be an early event, it is theoretically possible that a chemoprevention regime might be developed that would prevent tumour metastasis before the primary tumour was clinically apparent, enabling the bulk of human cancer to be cured by surgical resection.
In the present case, the factors favoring curative surgical resection were that there was no evidence of exposure of tumor or peritoneal dissemination, the recurrence had appeared late and was isolated, and the intra-abdominal recurrent tumor could be completely resected en bloc.
The combined use of gadolinium-enhanced scans with simpler criteria for dissemination in space and follow-up scans to ascertain dissemination in time appears to be a more fruitful avenue.
Sheriff Nice says that since arrest records in California are public information, dissemination does not appear to be a crime.
However, the length of time researchers had been engaged in active dissemination activities did appear to have an influence on impact.
However, tumor latency, growth and dissemination did not appear to change (Note: the inhibition was lost in the tumor cells that successfully colonized, suggesting that they were revertants).
In contrast, IL-17 appeared to enhance dissemination to the spleen during primary pulmonary Mtb infection.
