Sentence examples for disseminating cells from inspiring English sources

It cannot be known whether this phenotype is due to a selection process by the bone sites or to an intrinsic property of the disseminating cells capable of reaching the bones.

It is striking how rare the disseminating cells are (only 612 disseminating cells from PyMT tumor fragments were observed in a total of 48 multi-day movies).

During the ovarian carcinoma metastatic cascade, disseminating cells anchor to the mesothelium and submesothelial matrix of peritoneal organs [ 11, 13].

Understanding how MMP-1 and other members of the MMP family promote metastasis, in part by altering the signaling milieu in the tissue microenvironment colonized by disseminating cells may be crucial for developing more effective therapies for metastatic cancer.

In addition to this role for uPA in promoting localized invasion of BL-BCa cells, increased uPA activity was detected in highly disseminating tumor cells and implicated in regulating the intravasation of these disseminating cells [ 23- 25].

With respect to melanoma, this further coincides with recent evidence in mice that the metastatic transition is an early event, and that proliferation of disseminating cells is mediated by the function of CD8+ T-cells [ 46].

These registries have been established with the goal of systematically collecting, organizing and disseminating cell-line-specific information [ 23].

A varying fraction of the tumors in the individual data sets have disseminated cells to the lymph nodes.

Less than 0.00004% of initially disseminated cells complete the metastatic process, and yet, it is these few cells which lead that charge of cancer mortality.

Instead of facilitating metastatic tumors, however, these neutrophils diminish the survival of disseminated cells through CCL2-dependent activation of H2O2-mediated killing.

To disseminate, cells use a complex and multistage process known as the epithelial-mesenchymal transition, in which epithelial phenotype is transformed into mesenchymal phenotype.