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Otherwise, the intravascular hydrostatic pressure would lead to uncontrollable loss of fluid toward the interstitial space and disseminated tissue edema [1].
Otherwise, the intravascular hydrostatic pressure would lead to uncontrollable loss of fluid toward the interstitial space and disseminated tissue edema [ 1].
The microvascular structural and functional abnormalities seem to lead to the increased fibroblast activity and disseminated tissue fibrosis [ 12], which may progress to a clinical pattern of restrictive cardiomyopathy [ 13].
The disseminated tissue damage suggests that some secreted B. anthracis protease(s) distinct from LT may also serve a pathogenic role.
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Four weeks after inoculation, the mutant was not able to colonize heart or ear tissues, in contrast to the control, which disseminated to all tissues examined within 2 weeks.
In phagocyte-depleted larvae, infecting mycobacteria fail to disseminate to tissues.
S. typhimurium, like M. marinum, can survive intracellularly in macrophages of zebrafish embryos (Fig. 3B), but infected cells do not disseminate into tissues.
CTCs are cells that intravasate into the circulatory system from the primary tumor, while DTCs are cells that disseminate into tissues such the bone.
From initial replication in the MLN, MHV-68 is believed to be disseminated to other tissues by infected B cells.
B. burgdorferi producing OspC with 5-AA deletion disseminated to remote tissues, especially to the heart and ear at a remarkably slow pace in immunodeficient mice.
Within several days, Bb penetrates the vascular system and is disseminated to other tissues, inducing arthritis, cardiac complications, and neurological symptoms [1], [3].
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