A few can remain dormant for long periods of time, up to decades, and a very few activate and form a metastatic tumor that then begins disseminating a second generation of metastatic cells [ 52– 52].
The genes that may be selected to confer a growth advantage within the environment of the primary tumour site may not necessarily also confer an ability for the cell to be disseminated to a second, metastatic site where it may enter a long period of dormancy before again starting to proliferate.
SOME supporters of Mitt Romney, in an effort to make him seem more human (or at least humanoid), have been disseminating a story, first told by a biographer, about how their candidate has a charmingly eccentric habit: he eats only the tops of muffins.
But establishing beyond doubt who first disseminated an image is hard.
Mays was found guilty on a second count of disseminating a nude photo of a minor.
This process results in micro-metastatic, self-contained foci of cancer cells that persist clinically silent in multiple organs until one of these clusters acquires the necessary properties to establish invasive, colonizing growth, to become a detectable metastatic site and to re-disseminate systemically with a second wave of micro-metastasis.
The findings of this study demonstrate that the implemented 2-h HPV education program was successful for both girls and boys, and could be disseminated to both fifth- and sixth-grade students.
The reason given was that the evidence includes "certain materials that, if disseminated to third parties, could, among other things, pose a threat to public safety and the safety of witnesses, and could impede ongoing investigations".
In the century immediately after his death, Aristotle's works seem to have fallen out of circulation; they reappear in the first century B.C.E., after which time they began to be disseminated, at first narrowly, but then much more broadly.
The authors visited the various clinical departments and personally disseminated the first survey questionnaire to the experts who met the recruitment requirements.
