Zhu, J. et al. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks.
Zhu J, Zhang B, Smith EN, Drees B, Brem RB, Kruglyak L et al. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks.
The authors conclude that systems biology approaches can be used to identify master transcription factors that are involved in malignant transformation, and such approaches could be applied to help dissect the complexity of other tumour phenotypes.
We have a formal tool, with a solid multidisciplinary knowledge base, to dissect the complexity of ecological systems by moving from the reductionist analysis of their component parts (e.g., pairwise interactions) to the analysis of their macroscopic properties (Bascompte and Jordano 2007).
Many studies now provide compelling evidence that various genomic profiling approaches do have the capacity to dissect the complexity of cancers with the potential to then match drugs with patients [14], [37], [38], [39], [40].
Global DNA copy-number analysis integrated with gene-expression data can be used to dissect the complexity of breast cancer.
Overall, our results demonstrate the utility and also highlight some limitations of applying environmental genomics approaches to dissect the complexity of natural environments and the diversity of natural populations.
While additional work is needed to define the route of C. jejuni dissemination from the intestine and to dissect the complexity of systemic disease initiated by oral inoculation, we concluded that FlpA contributes to disease in the IL-10−/− germ-free mouse model.
Five tales dissecting the complexities of human relationships are in the running for this year's BBC National Short Story award.
References 46 and 48 do a good job of dissecting the complexities of Aurora-A regulation by the APC/C.
