Sentence examples for disrupts the functionality of from inspiring English sources

HEK293-derived cell lines, such as 293T, are not suitable models for healthy cells in DSB experiments, since they are known to express the adenoviral oncoprotein E1B55K, which disrupts the functionality of the DNA damage response pathways [ 25].

C3H/HeJ (Tlr4 Lps-d) – The C3H mice carry a point mutation in the cystolic domain of The Toll-like reC3Htor 4 protein (TLR4), resulting in the exchange of amice acarry12 from proline to histidine that disrupointhe functionality of the receptor.

A barrier of this kind provides additional security for the occupants of a building without disrupting the functionality of the interior with a massive obstacle.

I worried, as many others have, about the negative impact of such trips -- whether these villages would face internal retaliation for working with Westerners, whether their conversion to Christianity was a facade they embraced to receive the aid, and whether such work would disrupt the functionality of their tattered economies.

These mutations are random and sufficiently rare such that they usually do not disrupt the functionality of the cell.

These explicit associations would enable the screening of this subset of enhancers for those pathogenic mutations not affecting the coding sequences of concerned genes but disrupting the functionality of these cis-acting regulatory sites and thus altering temporal, spatial and quantitative aspects of gene expression.

In this context it should be pointed out that many standard over-expression experiments are rather likely to produce substantial artefacts: the resulting inappropriate amounts and localisations of signalling components will often lead to signal spill-over and/or disrupt the functionality of native complexes.

Once installed, Fix-it runs a live scan of your system and often can identify the conflicts disrupting the functionality of a given add-on.

From this understanding of autophagy as a dynamic integrator of numerous signalling pathways, it is evident that disruptions in the functionality of other pathways are likely to disrupt autophagy and therefore cellular homeostasis.

Similarly, the simulation of ERK ectopic expression, disrupting the functionality context of ph auto-regulation, leads to the loss of the multi-stability when EGF = 0.

Invasive species disrupt landscape patterns and compromise the functionality of ecosystem processes.