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Interestingly, the inability of TCBPA and TBBPA to activate hPXR suggests that the presence of the bromine or chlorine atoms proximal to the phenolic –OH weakens or disrupts on the O H O hydrogen bond with Ser247.
As an alternative to the DSCR theory, the "organicist concept" centers the DS pathogenesis on the developmental process and suggests that the presence of a trisomic chromosome, beside the specific function of the genes that it contains, disrupts on the whole the genetic homeostasis and leads to developmental instability.
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Next's stores were disrupted "on and off" for nearly a month, Wolfson said with outlets in Scotland and Northern Ireland the worst hit.
They disrupted on-field communications, spoiling broadcasts.
Bacterial meningitis is thought to disrupt on-going brain maturation in developing children [ 5].
But traffic was disrupted on one of the main routes to the convention arena as the opening gavel was summoning the Republican delegates.
All the communications disrupted on weekdays between nature and humanity have been restored on Sunday.
A2 The mayoral primary, disrupted on Tuesday, is reset for Sept. 25.
Service was disrupted on the A, C and D subway lines for nearly two hours.
That effort was disrupted on Saturday as lorries carrying supplies into Homs came under heavy fire.
Some subway lines on the West Side of Manhattan were also disrupted on Sunday, because of track work.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com