Sentence examples for disruptive mutation from inspiring English sources
We analyzed dimers wherein one subunit harbors a disruptive mutation and observed that ATP binding by both subunits is essential for function in yeast, whereas ATP hydrolysis is only required in one subunit.
They have a disruptive mutation in the gene for the blood cell molecule hemoglobin; as a result, their red blood cells typically take on a sickle shape, which causes them to clog up blood vessels, leading to intense pain, especially in the long limb bones.
Interestingly, brown hyena UGT1A6 possessed a single disruptive mutation (M10) that was identical in nucleotide sequence and location to one of the mutations (M1) found in all felids.
Repetitive non-selective streaking of FM145 readily results in strains with increased autofluorescence, indicating that the change in FM145 is most likely due to the reduced synthesis of a fluorescent compound rather than to a disruptive mutation (not shown).
Of 109 tumors with p53 mutations, 76 (69.7%) and 33 (30.3%) were classified to harbor a non-disruptive mutation and a disruptive mutation, respectively.
As none of the tumors harboring a disruptive mutation was HPV-positive, multivariate analysis of a disruptive mutation at a risk of HPV infection was prohibited.
In total, we have identified 515 SMGs which were significantly mutated, and 156 TDGs with disruptive mutations in both tumor samples.
Since our purpose was to identify tumor-specific disruptions, we only focused on tumor-specific disruptive genes (TDGs) which contain disruptive mutations in the two tumor samples but not in any normal samples.
Taken as a group, however, genes involved in neural function and development showed greater rates of disruptive mutations in patients," said Shaun Purcell of the Broad Institute in Cambridge Massachusetts.
MSUD is genetically caused by disruptive mutations in three genes including the BCKDHA, the BCKDHB, and the DBT.
No disruptive mutations were detected in any of the UGT1A1 sequences evaluated.
