An aspect is required to be as tolerant as possible of disruptive external modifications, e.g. if one of its necessary columns is deleted, it will recreate the column using default values.
Here, the most disruptive post-translational modification was Thr OGlcNAcylation, which rendered the peptide almost fully random coil.
Notably, while both post-translational modifications were disruptive at the interior and at the C-terminus of α-helices, for threonine the effects of phosphorylation and OGlcNAcylation were observed to be greater at the interior of α-helices than at the C-terminus, whereas for serine the effects were comparable in both locations.
First, the BBB is compromised in pathological conditions such as inflammation and tumor development, and under pharmacological modification with BBB specific disruptive agents (Bartus et al., 1996; Boskovitz et al., 2004; Elliott et al., 1996; Stamatovic et al., 2008; Wang and Casley-Smith, 1989; Wolburg et al., 2005).
The modifications on the linker showed no disruptive effects on the fluorescence intensity of labeled cells analyzed by both flow cytometry and live-cell imaging.
In addition, these findings suggest that modifications of glutamate receptor phosphorylation could mediate the disruptive effects of stress on cognition.
But how do you know if you never try anything else?" Behavior modification for A.D.H.D. and for related problems, like habitually disruptive or defiant behavior, is based on a straightforward system of rewards and consequences.
Importantly, the non-covalent modification of PCPP immunoadjuvant with polyethers introduces pH dependent membrane disruptive activity, which is not characteristic for PCPP itself, and is typically correlated to the ability of macromolecular carrier to facilitate endosomal escape.
MW's challenging and disruptive behaviours, notably obsessive checking of car suspension by rocking, and wandering, responded to behavioural modification regimes adapted from the neurorehabilitation literature.
