Exact(3)
So it becomes all the more urgent for us to somehow create work that continues to have a disruptive function, but without being immediately identifiable as such," explains Slavs and Tatars.
Because of the importance of cadherins in cell recognition, adhesion, sorting and signalling, their disruptive function of P-cadherin has significant implications in disease states, including cancer.
In addition, CBMs isolated from both bacteria and fungi have been suggested to facilitate cellulose hydrolysis by physically disrupting the structure of the fibrous cellulosic network and releasing small particles, without showing any detectable hydrolytic activity, which is normally quantified by the release of reducing sugars (the so-called disruptive function) [ 7, 8].
Similar(5)
The cytotoxicity of Mtb did not depend on the reported membrane-disruptive function encoded by genes of the mycobacterial RD1 region [6].
However, many of these insertions will be disruptive of function (e.g., those occurring within coding regions).
In these cases, laboratory evolution can be used to identify which of the many possible fission sites within a protein are least disruptive to function.
We implemented this strategy in our third approach, namely, the SNAPMAT score (Fig. 3 C ; Materials and Methods; Supplemental Table 4) that is most sensitive to mutations disruptive to function but not structure.
While the precise molecular identity of the most toxic Aβ species is debatable (for example, [ 69]), the number of independently reproduced reports implicating soluble Aβ as disruptive to normal function strongly suggests that this species plays a key role in the cognitive decline observed in AD.
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