Thus, a full genetic dose of the stat92E gene is required for the disruptive effect of ept loss on epithelial organization, and this appears to correlate with a requirement for stat92E in controlling Crb in ept mutant cells.
To obtain further support for the disruptive effect of these mutations, we have expressed three of the MAGEG1 mutants (full-length) together with NSE4b in HEK293 cells and examined their interactions with NSE4b by immunoprecipitation from cell extracts (Figure 5B).
However, this line of reasoning might overstate the disruptive effect of an abundant supply of alternative partners for one of the spouses.
The search for an impartial and neutral tool to mitigate the disruptive effect of factionalism was an important feature of political life in Italian city republics.
Even if we stopped burning all fossil fuels immediately, the disruptive effect of accumulated CO2 in the atmosphere is guaranteed to hammer us for decades.
The disruptive effect of non-adherence on asthma treatment implies that solutions are needed for improving adherence.
This disruptive effect of new technology is familiar to historians and the mechanization of agriculture, for example, forced farm laborers to migrate to cities in search of work where they encountered pollution, poverty, and disease.
Indeed, this potentially disruptive effect of lipid movement may explain why the scramblase activity is non-specific for phospholipid headgroup.
An obvious one is the potentially disruptive effect of new trade routes.
The potential disruptive effect of human germ line editing seems very small, compared to the potential effects of other applications of high precision genome editing, for example, the use of gene editing that influences ecosystems (Lunshof, 2015).
