In our discovery set of ten tumor/normal subject pairs with Gleason scores of 8 10 at diagnosis, coordinated analysis of germline and somatic variants, including single-nucleotide variants, indels, and structural variants, revealed biallelic BRCA2 disruptions in a subset of samples.
We sought to determine whether chaining behavior resulted from a shared disruption or whether subsets of the chaining lines showed the same overall phenotype as the consequence of perturbations in different neural processes.
In heterozygous human and murine muscle tissue the IF pathology is characterized by focal disruptions of the IF network in a subset of fibers.
DOCK8 was also present in all lymphocyte subsets of ERU cases, but with considerably decreased levels (geo MFI) in all lymphocyte subsets analyzed (Fig. 3D).
In conclusion, we suggest that in a subset of patients with Alzheimer's disease there is progressive disruption in language integrity, detectable from prodromal stages, which is best captured by measures of semantic and lexical content and syntactic complexity.
We also observed a marked disruption of gray-white matter borders in a subset of the chimeric embryos (Fig. 6I, rectangle, enlarged in J N; n=3/18), similar to the phenotype observed in tsc2 vu242/vu242 mutants (Fig. 5E-H).
However, this over-representation of initial frame disruptions in the 'non-NMD' region also arises for the subsets of transcripts in which the frame disruptions disrupt a SCOP protein structure domain (P < 0.05), and which are thus unlikely to form a stable functional protein product.
This suggests that axonal transport disruption is mechanical, and not simply functional, in a subset of axons at very early time points.
Although, post mortem verification of EB extravasation in a subset of animals did not reveal macroscopic disruption of the BBB at the time of scanning in our study, this might be a potential confounder.
76 As hemorrhagic transformation is associated with severe BBB disruption and is one of the major complications of thrombolytic tPA therapy, it may be that in this subset of patients thrombolytic tPA contributes to an increase in early poststroke seizures.
