These include developmental rodent models that focus on observed malformations and pathologies in the mammary gland, reproductive tracts, external genitalia, and the brain and the resulting disruptions in function of these tissues.
Fibromyalgia is experienced as a chronic, widespread pain condition accompanied by fatigue, tenderness, sleep disturbance, decrements in physical functioning, and disruptions in psychological functioning (for example, memory problems, diminished mental clarity, mood disturbances, and lack of well-being) [ 5, 6].
Orbitofrontal function is known to be impaired in adults with cocaine dependence (58); specifically, disruptions in orbitofrontal functioning have been associated with compulsive features of stimulant drug dependence (59,60).
For example, disruptions in the functioning of the interbank market may lead less liquid banks, or banks less able to attract depositors to cut business lending.
Either way, brain injury produces an "utter quagmire" of specific disruptions in brain functioning that doctors have only blunt tools to fix, said Dr. Jonathan Fellus, director of the brain injury program at the Kessler Institute for Rehabilitation in West Orange, N.J.
In this case, the apparent loss of Fab-7 insulator activity would have to be an indirect consequence of disruptions in the functioning of the neighboring dCTCF-dependent insulators, Fab-6 and Fab-8.
Disruptions in endolysosome functions perturb numerous cellular functions and can ultimately result in the initiation of cell death pathways (Kroemer and Jaattela, 2005; Kurz et al., 2008).
Concussion — the word derives from the Latin concutere, meaning shake violently — is typically followed by dizziness, headache, nausea, lethargy, impaired vision or other disruptions in brain function.
The techniques allow scientists to see disruptions in brain function, which lets them sketch a physical map of what might be going on in the minds of modern-day hysterics.
However, in understanding these mechanisms it has become clear that many of them overlap with our ability to respond to disruptions in tissue function caused by trauma or deterioration.
