Aberrant TJ morphology observed in MS brains correlated with enhanced BBB leakiness for serum proteins, highlighting that BBB TJ disruption underlies BBB leakiness in MS [ 25, 37].
Also, the complex feedback network composed by epigenetic pathways and miRNAs (including, among others, Let-7a) forms an important regulatory circuit, whose disruption underlies a variety of pathological phenotypes and cancers not always related to the liver, which may complicate our understanding of diseases [ 125].
SAN FRANCISCO — Even before Electronic Arts roiled the video game world on Sunday with its $2 billion hostile takeover bid for Take-Two Interactive, even before Phil Harrison, president of Sony's worldwide game studios, announced his resignation on Monday, one could plainly see the creative and financial disruptions underlying the industry's explosive growth.
The membrane perturbations induced by amphipathic peptides in vesicles often show sigmoidal concentration dependence, and as indicated by peptide cross-linking experiments [18,26], this can indicate cooperativity in the peptide-induced membrane disruption that underlies efflux of vesicle-entrapped molecules.
Our results, in combination with data from earlier studies by our group (Sack et al., 2007, Cerebral Cortex), lead to informed speculations on complex brain mechanisms, and TMS disruption thereof, underlying visuospatial judgment.
Although there was obvious evidence of muscle disruption, the underlying cause was not clear.
This might result from some form of compensatory activity that attempts to maintain a selective muscle command despite disruption in underlying patterns of brain activity.
Taken together, these findings underscore the importance of healthy myelinating oligodendrocytes in maintaining the axonal domains at and near nodes, and further demonstrate that nodal disruption may underlie the pathophysiology of various conditions associated with CNS demyelination.
Pathogenic effects of Tag1-specific T-cells were demonstrated in EAE, an animal model of MS. Taken together, these findings suggest that the functional domains at and near nodes are potential targets of autoimmune reactions, and, consequently, immune-mediated nodal disruption may underlie the pathophysiology of a broad range of neurological diseases.
"Survey respondents reported the weakest growth of output and new orders for three months in January, but with many companies blaming exceptionally cold weather for production and supply chain disruptions, the underlying trend looks to have remained robust.
The search has stalled badly; while these disorders may involve genetic disruptions, no underlying patterns have surfaced — no single gene or genes that account for more than a tiny fraction of cases.
