Thomas Thurston built a dataset at Intel which he later refined to test disruption theory.
Since the patterns I found were more than 25percentt accurate, and those patters seemed to dovetail with what Christensen had long written about, I decided to test Disruption Theory on its own.
Biotinylated CM79 antibody was also used to test disruption of the CM79-identified epitope in ELISA (B) and in competition assays to measure the proportion of human antibodies that were directed against the CM79-identified epitope in ELISA (C).
To test disruption of FAK and p53 binding by R2 in cells, we performed immunoprecipitation (IP) of FAK and p53 proteins in HCT116 p53+/+ cells without R2 and with R2.
To test whether disruption of platelet function with clopidogrel and aspirin would decrease the number of circulating tumor cells (CTCs) in patients with metastatic breast cancer, a randomized phase II study was performed.
To test whether disruption of the ROCK-I RhoE inteROCK-I RhoEts RhoE interfaceon with ROCK-I, RhoE affectscids ThRhoE and Val192 of the β6 strand and α5 helinteractionively, with mutated to arginines.
To test whether disruption of zinc coordination would result in a similar phenotype as deleting C33, we mutated the three cysteines in the CHCC motif of endogenous Dcr1 into serines (Dcr1-CHCC to Dcr1-SHSS).
To test whether disruption of SDF-1 signaling could attenuate OA pathogenesis in vivo, we treated the primary Hartley guinea pig OA model with AMD3100, a specific nonpeptide CXCR4 chemokine receptor antagonist [ 35].
To test whether disruption of Fyn kinase signaling caused a decrease in myelin sheath generation by oligodendrocytes, we took a previously validated Morpholino-based approach (Jopling and den Hertog, 2005) and observed a reduction in myelination, without any obvious defects in general development.
To test if disruption of an origin of replication can increase the local mutation rate in an early-replicating/low mutation rate region, the earliest and most efficient origin, ARS607, was deleted in strain GL·36, where the URA3 gene is located 3 kb away from the origin.
