Thus, Rps27l has dual functions in p53 regulation: under Trp53 +/+ background, Rps27l disruption triggers ribosomal stress to induce p53 and apoptosis, whereas under Trp53 +/− background, Rps27l disruption triggers genomic instability and Trp53 deletion to promote tumorigenesis.
Some of these studies have identified specific signaling pathways that are used by these toxicants to induce disruption at the Sertoli Sertoli and/or Sertoli germ cell interface, perturbing the blood testis barrier (BTB) function and germ cell adhesion.
Microtubule disruption has been shown to induce dramatic alterations in both the assembly and the spatial localization of SGs and PBs in different cell lines [29], [30], [31].
This activity appears to be mediated through the disruption of tubulin dynamics to induce cell-cycle arrest in the G2/M phase and apoptosis.
Protease activity of dust mite allergen can act on airway epithelial cells to induce disruption of the tight junctions between epithelial cells and activation of protease-activated receptor-2 (PAR-2), facilitating allergen delivery across epithelium (Jeong et al. 2008).
In this article, we present data from detailed investigations of the ability of combinations of androgen receptor (AR) antagonists to induce disruption of male sexual differentiation after long-term exposures in utero and postnatally.
Among molecules that regulate Beclin-1 Bcl-2 interaction, AMPK-JNK activation has Beclin-1 Bcl-2to interactionuption of Beclin-1–Bcl-2 interaction through phosphorylation of Bcl-2 activation 15], whaseas activation of mammalian sterile 20-like kinase 1 (Mst1) promoted beenin-1/Bcl-2 intereportedby phosphorylatoon of Beclinducet Thr108 [ 11].
In males, perinatal exposure to BPA affects fertility and has the potential to induce disruptions in Sertoli cell junctional proteins, which have a crucial role in spermatogenesis.
The search for an Aβ species that is capable of causing cognitive disorder as observed in AD patients led to several reports of animal-cell derived [ 13, 47, 48], humanderived [ 10] and synthetically prepared [ 9, 49- 52] oligomers that have been found to induce disruptions of synaptic activity in vitro or impair cognitive function in animal models.
Evidence indicates that BBB disruption by thrombin is at least partly PAR mediated [ 56, 58] and that thrombin phosphorylates Src kinases to induce endothelial disruption [ 56].
