Thus, our studies suggest that short-term pacing results in significant reductions in Cx43 transcription and/or mRNA stability, altered intracellular distribution of gap junction protein, and a disruption in the process of degradation of Cx43.
"Any disruption in the process runs the risk of stalling or stopping development — and curtailing one of the great sources of real estate and wage taxes that pay the city's regional bills," the report said.
This may suggest that one or more of these molecules are critical for the "movement" of islet structures away from the ducts during islet morphogenesis, and its down-regulation caused a disruption in the process.
Disruption of the process, by knockdown of the genes Hen1 and Ago2, leads to shorter lifespan and neurodegeneration.
Dysphagia is the result of disruption in the process of coordinated contraction and relaxation of the masticatory muscles, tongue, pharynx, and esophagus.
Another possible explanation is that for the majority of women, a miscarriage is not a significant disruption in the process of becoming a mother.
They will try to uphold every day life, but a normal course of life is out of reach; this leads to a disruption in the process.
Each of these changes takes place in a strictly choreographed series, and disruption of the process can lead to dramatic and long-lasting consequences.
Following a major disruption, the recovery process involves multiple stages, and during each stage, the partially recovered infrastructures can provide limited services to users at some degraded service level.
Human intervention is of course not practical in any mass digitization process, as it would cause far too large disruptions in the process.
