Exact(1)
Schizophrenia is associated with significant circadian disruption, the core aspects of which include abnormal phasing, rest and activity fragmentation, and reduced stability in rest and activity behavior, as illustrated here by a typical human activity profile [ 1, 17 19].
Similar(59)
If accretion is violently cataclysmic, physical disruption of the core renders this scenario implausible.
For the best-financed universities, seeking the highest expected returns while anticipating losses including some large ones that are tolerable in the sense that they can be absorbed without fundamental disruption of the core mission of the institution seems to be the right answer.
Our observation that disruption of the core LXXLL motif did not result in suppression of IL-12 secretion is in contrast to reported observations using purified Vpr protein in monocyte cultures.
Disruption of the core formation is an established target for N- and C-peptide fusion inhibitors, which are derived from the NHR and CHR regions respectively [ 16– 20].
To establish whether the Bdr phenotype might be related to disruption of the core molecular clock, we undertook both in vivo and in vitro approaches.
There were large numbers of Stra8-positive cells in heterozygous XY gonads, again indicative of activation of the ovarian pathway due to disruption to the core testis-determining gene regulatory network.
They found that the unfolding occurred through the disruption of the hydrophobic core and the unfolding of the helix.
As a result, we elected to use this model to explore the impact of circadian disruption without genetically altering the core molecular circadian clockwork.
The core finding, disruption and change, illustrates the range of perceived consequences of knee symptoms in peoples' lives.
(Davis, age 61, focus group 5) The core finding, disruption and change, illustrated the consequences of knee symptoms on peoples' lives (figure 1).
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