Sentence examples for disruption severely from inspiring English sources

Finally, maintenance of the NeuroD6-induced mitochondrial mass required an intact cytoskeletal network, as its disruption severely reduced mitochondrial mass.

Maintenance of the NeuroD6-induced mitochondrial mass requires an intact cytoskeletal network, as its disruption severely reduces mitochondrial mass.

In contrast, disruption of dimerization severely impairs IKK2 trans autophosphorylation in vitro.

Heparin binding haemagglutinin adhesin (HBHA) enables M. tuberculosis to bind to sulphated glycoconjugates on epithelial cells; disruption of its synthesis severely impairs the ability of bacteria to disseminate from the lungs to the spleen.

Measurement of flux and velocity revealed that axonal transport of synaptic vesicle precursors was not altered severely by disruption of mtDNA replication.

In our ferret model of cortical dysplasia, the expression of BLBP in radial glia is decreased after MAM treatment; however the remaining BLBP+ radial glial cells are relatively spared from disruption compared with the severely disorganized vimentin+ cells.

nNOS disruption also results in severely impaired myocardial relaxation both in vivo [17,19] and in isolated myocytes [15,16,20].

Not surprisingly so, disruption of LINC complexes severely affects viability, development, and reproduction (Kracklauer et al. 2013; Starr and Fridolfsson 2010).

AD is often accompanied by inflammation of the brain blood barrier (BBB), and the disruption of its permeability severely compromises neuronal homeostasis [ 12, 13].

These data suggest that full Abl activity requires the observed I164-mediated interaction of the SH2 domain with the kinase domain and that disruption of this interface severely compromises phosphorylation of Abl substrates in cells.

An Fe2+-binding site located on the inner surface of the subunit, ∼10 Å away from the ferroxidase site and coordinated by His46, Asp50, and three water molecules, was subsequently identified.[ 3c] Disruption of this site severely inhibited mineralization, consistent with an important role in electron transfer from Fe2+ ions in the cavity to the ferroxidase site.