The cell lysis (i.e., cell disruption) releases soluble organic compounds including lipids from microalgae cells (Ahn et al. 2002; Huang et al. 2014).
Compartmentalized within host cells to avoid self-toxicity, cyanogenic glycosides are cleaved upon tissue disruption releasing toxic hydrogen cyanide (HCN).
This leads to inflammasome activation, release of proinflammatory cytokines, damaged DNA, and metabolic enzymes and, ultimately, cellular disruption releasing other DAMPS.
Cavitation is a phenomenon having enormous potential for intensification of physical and chemical processing applications such as chemical synthesis, industrial wastewater treatment, cell disruption for release of intracellular enzymes, crystallization, extraction and leaching.
Nonetheless, we found that HMDM and J774A.1 cell death was dependent on YopJ/YopP expression as indicated by severe membrane disruption and release of cytosolic components (Fig. 1 and Fig. 2).
Short-circuiting of ionic balance due to MPT results in increased organellar swelling leading to outer membrane disruption and release of pro-apoptotic factors.
Rhabdomyolysis (RM) is a clinical syndrome characterized by injury to skeletal muscle fibers with disruption and release of their contents into the circulation.
Uptake of NPs by toxin-coated tumor cells leads to coendocytic uptake of particles with cell-bound toxin; the particles trigger endosome disruption and release of the toxin for tumor cell killing.
Practical conclusions from these observations are that more efficient cell disruption and release of specific protein could be possible with combined process variables and it was possible to conduct cell disruption experiments in a scaled-down homogenizer and confidently applying the results to larger scale units which saves considerable volume of material required to be processed.
Monocyte inflammatory products released during sepsis, especially TNFα, have been shown to impair skeletal muscle contractility through an increase in mitochondrial or cytosolic production of reactive oxygen species (ROS) [ 18], and calcium-activated calpains lead to Z disk disruption and release of myofilaments, a phenomenon that has been shown to be up regulated in sepsis [ 18].
