Sentence examples for disruption or interaction from inspiring English sources

Mahogunin ring finger-1 (MGRN1) is a cytosolic ubiquitin ligase whose disruption or interaction with some isoforms of cytosolically exposed prion protein leads to spongiform neurodegeneration and also lack of which results in reduced embryonic viability due to mispatterning of the left right (LR) axis during development.

Furthermore, tumors are heterogeneous and involve non-standard or unique disruptions or regulatory interactions, rendering GRN inference even more challenging [ 19].

Consequent changes in plant pollinator interactions can include weakening or disruption of interaction networks and can eventually lead to a possible loss of pollinator species in the Mediterranean systems (Hegland et al. 2009; Scaven and Rafferty 2013; Petanidou et al. 2014).

An important area of future research will be to unravel the complex interactions between the EBV-infected B cell and its microenvironment and to determine how disruption or modification of these interactions might be tumor-promoting.

Mutations in the KCNE1 C-terminus may thus affect the normal interaction between the proteins via disruption or the formation of new interactions that are consequential to deactivation rates.

These phenotypes parallel those observed upon knockdown of Rab11 or disruption of Rab11/FIP3 interaction, and we have previously shown that Rab11/FIP3 mediates an interaction between recycling endosomal-derived vesicles and the Exocyst.

Suppression of NL expression by RNA interference (RNAi) or disruption of Nrx/NL interaction consistently reduces the number of synapses (Chih et al., 2005; Levinson et al., 2005).

As disruption or altering of cell-cell interactions is an important feature of tumour invasion and metastasis, it could therefore be hypothesised that one working CADM1 allele is insufficient to accomplish the normal gene function.

The idea that abnormal alteration (disruption or enhancement) of specific protein interactions can lead to human diseases complements canonical gene loss/perturbation models and provides new clues on mechanisms underlying human diseases [ 67].

Initiation is targeted by a number of regulatory pathways linked to cellular processes such as cell growth, differentiation, and environmental stress responses (Sonenberg and Hinnebusch, 2009), and the functional disruption or decoupling of these regulatory interactions has been observed in a number of cancers (Ruggero, 2013).

Disruption of this interaction or inhibition of LEF1 translocation to the nucleus leads to apoptosis in leukaemia cells, implying that LEF1 may be an attractive therapeutic target for CLL therapy.