And "health" is described as being "free from disease or abnormality".
Disruption or misregulation of the Shh pathway results in various developmental abnormalities including holoprosencephaly, Pallister Hall syndrome, Gorlin syndrome, Greig cephalopolysyndactyly, Rubinstein Taybi syndrome and different types of cancer (basal cell carcinoma, medulloblastoma, glioma, breast, pancreatic, prostate cancers and more).
There is a possibility that the phenotypic abnormalities in our study could be due to the disruption or deletion of a microRNA expressed from this intron [ 35].
We found that 25.5% of shHP1γ cells in mitosis displayed abnormalities (n = 200, Figure 5C), including multipolar spindles, centrosome disruption or lagging, unorganized chromosomes.
No disruptions of the glia limitans or abnormalities of Bergmann glia orientation were observed despite a nearly complete loss of PC dystroglycan.
Moreover, IRE1α disruption causes histological abnormality of the pancreatic acinar and salivary serous tissues and decrease of serum level of immunoglobulin produced in the plasma cells, but not dysfunction of liver.
The supposition that casting and curing at near freezing temperatures leads to the loss of stiffness of the hardened concrete and causes microstructure disruption and abnormalities was investigated.
Interestingly, mutations in DNAJC11 in the mouse result in mitochondrial disruption, cristae abnormalities, and motor neuron pathology (Ioakeimidis et al., 2014).
Locostatin treatment of depleted or RKIP−/− MEFs reveals cytoskeletal disruption and microtubule abnormalities in the spindle.
Then the agent widened the policy to include extensions or "abnormalities".
