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The volume also contains a section on the molecular mechanisms of maintenance and disruption of virus latency.
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The disruption of Epstein-Barr virus latency in B cells is induced by expression of BZLF1 immediate-early protein, and this transcription is negatively regulated by YY1 [227], [227].
To explore if the extracellular effect of S. nigra extract on IBV infectivity was due to physical disruption of the virion, virus samples treated with S. nigra extract or solvent alone were negative stained and examined by transmission electron microscopy.
Microtubules were perceived to assist WNV envelope and capsid proteins transported from the perinuclear region to plasma membranes, probably for assembly before releasing virus particles, and disruption of microtubules could markedly reduce virus titres [ 8].
Fluorescence experiments were carried out with an excess of liposomes to disfavour disruption of liposomes by multiple virus particles.
S.M. Lemon and K. Li review the data documenting hepatitis C virus disruption of innate intracellular antiviral defenses, including interferons and toll-like receptors.
Interestingly, arginine at residue 399 is highly conserved and is more important for CXCR4 binding, with even a conservative substitution of R399K resulting in disruption of CXCR4 binding and abrogation of virus entry.
Kunjin virus yield was apparently slightly reduced when cytochalasin B drug disrupted the organisation of actin filaments, and this event suggested the possibility that any form of disruption could have affected the egress of virus particles [ 65].
Virion stability was evaluated by a urea disruption assay and by testing the infectivity of virus following purifications.
Disruption of the Moloney murine leukemia virus (MMLV) PPPY element gives rise to budding defects similar to those observed for HIV-1 PT/SAP mutants [12].
In men, mumps virus causes disruption of spermatogenesis (Dejucq and Jegou, 2001).
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