Sentence examples for disruption of the interface from inspiring English sources

Disruption of the interface generated either soluble tetramers or putative dimers that were absolutely insoluble and inactive.

The integration of a temperature-responsive polymer on the electrode surface enables easy manipulation of the biological sensing interface (i.e., addition of biotin, streptavidin, and antibody), thus allowing for temperature-induced regeneration and disruption of the interface architecture of the electrode surface.

This suggests that the trigger for subunit exchange does not involve the disruption of the interface between the kinase domain and the hub that is seen in the structure of the autoinhibited holoenzyme.

This may reflect the fact that a simple weakening (as opposed to total disruption) of the interface is insufficient to affect the physiological function of the interaction, or that the molecular consequences of the mutations are not manifest by simple suppression of Eco1 deficiency.

Since the second phase of decoding involves disruption of the interface between EF-Tu and aa-tRNA, accommodation of the aa-tRNA into the A site, and the subsequent formation of the dipeptide bond, it seemed possible that EF-Tu interface mutants could alter kpep, the rate of dipeptide bond formation.

These observations also provided a prediction that disruption of the interfaces within the yeast Ire1 oligomers has little impact on RIDD cleavage.

Besides disruption of the interfaces of both proteins, it is important to ensure that the binding of the peptides, if to the toxin, does not hinder the catalytic activity of the toxin, so that the released toxin can still act on its target to kill the pathogens.

Disruption of this interface inhibits the downstream events critical for chronic myelogenous leukemia signaling.

Disruption of this interface abolished the development of CML in a mouse bone marrow transplantation model and enhanced TKI sensitivity of nonmutated and TKI-resistant Bcr-Abl forms.

Desensitization has been linked to disruption of the dimer interface between GluA2 LBDs, while stabilization of a symmetrical dimer interface by a mutation (L483Y) reduces desensitization.

These data suggest that full Abl activity requires the observed I164-mediated interaction of the SH2 domain with the kinase domain and that disruption of this interface severely compromises phosphorylation of Abl substrates in cells.