Increase in water problems in the basin of Lake Balkhash, associated with extensive development of the water sectors for the economy, leads to disruption of the functioning sustainable, natural and economic systems of the region.
For even in those cases where a mutation contributes positively to the function of one trait, the chances are that it will contribute negatively to overall fitness in virtue of its disruption of the functioning of other traits.
In 2015, a technical paper facilitated by UNISDR suggested amending the definition to read, "a serious disruption of the functioning of the community or society due to hazardous events interacting with conditions of vulnerability and exposure, leading to widespread human, material, economic and environmental losses and impacts" (emphasis added) (UNISDR 2015).
A disaster is a serious disruption of the functioning of a community or a society involving widespread human, material, economic, or environmental losses and impacts that exceed the ability of the affected community to cope using its own resources (Wisner et al. 2004; Birkman 2006; UNISDR 2009; Coppola 2011).
According to the United Nations International Strategy for Disaster Reduction (UNISDR), disasters represent "a serious disruption of the functioning of a community or a society involving widespread human, material, economic or environmental losses and impacts, which exceeds the ability of the affected community or society to cope using its own resources" (UNISDR 2009, p. 9).
The UN Office for Disaster Risk Reduction (UNISDR) (UNISDR 2009) defines disaster as "a serious disruption of the functioning of a community or a society involving widespread human, material, economic or environmental losses and impacts, which exceeds the ability of the affected community or society to cope using its own resources" (emphasis added).
Thus, new horticultural crops with semi-dwarf phenotypes or more branches could be generated by the disruption of the functions of these gene homologs using genome-editing technologies.
Disruption of the function of the genes in the GA or SL biosynthetic or signaling transduction pathway could result in various phenotypes such as dwarf6 and excessive outgrowth of axillary buds,88,89 respectively.
Overall, this implies that the disruption of the function of the paraspeckles is correlated with the increasing signs of deterioration of normal transcriptomic state of the cells.
Simultaneous disruption of the function of all three RACK1 genes results in lethality.
It has been suggested that the superior clinical efficacy of tubulin inhibitors is due to disruption of the function of microtubules in interphase cells [ 38].
