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This leads to the disruption of the functional integrity of the GBM and the filtration barrier, which in turn results in proteinuria.
Gene 1 extended only with the disruption of the functional stop codon and if another stop codon was present downstream in the same frame.
The reduction of CPS production by SAL is likely the result of either the modulation of enzyme activity in CPS synthesis pathways or the disruption of the functional integrity of KP outer membranes.
The antimicrobial activity of telavancin results from a dual mode of action, including inhibition of peptidoglycan synthesis and disruption of the functional integrity of the bacterial membrane [ 2, 3].
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Aphasic individuals, as a group, demonstrated a selective disruption of the normal functional connections between the left and right anterior temporal lobe.
As a group, aphasic patients demonstrated a selective disruption of the normal functional connection between left and right anterolateral superior temporal cortices.
Since there are no sequence gaps upstream of this locus where that exon might be located, this copy is partial, with a likely disruption of the main functional domain.
Aphasic patients, however, demonstrated a selective disruption of the normal functional connection between the left and right anterior temporal lobe, indicating that the deficits in auditory single word and sentence comprehension were related to the degree of this left-to-right anterior temporal lobe disruption.
Disruption of the hypothesised functional linkage between mood and level of identification means that, despite experiencing persistent and exacerbated negative mood, a depressed individual may not derive the potential benefits of concrete processing on problem solving, planning, focused attention, and reduced emotional response, when faced with a loss or difficulty.
In turn, STX in neuronal cells is found to reside inside PIP2-enriched plasma membrane compartments, suggesting that the effects of PIP2-sequestering palpeptide may stem, at least in part, from disruption of these functional domains.
These results confirm our previous ultrastructural findings [39] on disruption of the BSCB showing functional incompetence of BSCB structural elements in ALS mice.
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