Sentence examples for disruption of the complex from inspiring English sources

While this interaction is extremely efficient in trapping IgG molecules, the tight interaction between the binding partners often requires denaturing conditions for disruption of the complex, which can adversely affect the yield of purified IgG and also limit the lifetime of the receptor matrix.

It has previously been shown that cadherins regulate intercellular adhesion in neural progenitors and that a disruption of the complex formed with α- and β-catenin leads to increased Shh signaling and proliferation [53].

Once the binding regions of AKIP 1A with PKAc and p65 had been identified, we next wanted to determine whether disruption of the complex played a functional role in cells.

In 15% n-butanol and/or at lower ionic strength (128 150 mM ammonium acetate cf 200 mM Fig. 1, 2) spectra could be recorded that are consistent with further disruption of the complex (figure S2).

More recently, Gao et al. argue that the mechanism of transcriptional repression by VENTX is caused by the disruption of the complex between β-catenin and TCF/LEF factors [48].

First, inhibition of protein phosphorylation after the formation of U1-70K/SR45 did not result in the disruption of the complex although a clear rearrangement of the complex into enlarged irregular speckles was detected.

The disruption of the complexes dominates the kinetic swelling of MAA enriched gels under basic conditions.

αSNAP binds to these complexes and recruits N-ethylmaleimide-sensitive factor (NSF), an ATPase that catalyzes the disruption of the complexes rendering active monomeric SNARE proteins.

Substructure is sought by solution disruption of the complexes as described below.

DHX34 is recruited to the SURF complex via its preferential interaction with hypophosphorylated UPF1 and subsequently promotes UPF1 phosphorylation concomitantly with a disruption of the SURF complex.

Because the level of hypersecretion was lower than that expected based on the disruption of the AP-3 complex, we hypothesize that other classes of vacuolar enzymes involved in the degradation process may also require the AP-3 complex for correct sorting.