Sentence examples for disruption of specific from inspiring English sources
Furthermore, these results suggest that disruption of specific interactions at PKC putative consensus sites can render α4β2 nAChRs almost insensitive to nicotine without substantial effects on normal AChR function.
The identification of constitutively activated STAT (Signal Transducers and Activators of Transcription) proteins in aberrant cell signaling pathways has led to investigations targeting the selective disruption of specific STAT isoforms directly associated with oncogenisis.
Further studies revealed that disruption of specific LAP-thrombospondin-1 (TSP-1) interactions prevented LAP-induced responses.
However, even if a large number of mutant strains already exists or may potentially be available, targeted modification or disruption of specific DNA regions is difficult to achieve.
Mutations that block the formation of cilia, either by blocking IFT or through disruption of specific basal body proteins, prevent the normal regulation of Gli transcription factors in response to Hedgehog ligands [reviewed in 2], [3], [4].
As in the case of single gene mutations, the disruption of specific pathways may be exploited therapeutically.
The recipient cells carried disruptions of specific TLS DNA polymerase genes, or had TLS polymerase gene expression suppressed by siRNA technology.
Since some key mechanical properties of cells are dependent on the cellular cytoskeleton, we first assessed changes in cytoskeletal distribution in cell sheets lifted from a plating substrate, as well as from disruptions of specific cytoskeletal components.
The disruption force of specific biotin-streptavidin bonds was determined using DNA oligomers as force tags.
Notably, our conclusion is supported by recent studies of glioblastoma, that also showed higher than expected disruption frequencies of specific genes when multiple genomic dimensions were analyzed [ 39, 40].
Incubating dissected tick synganglia in vitro for 6 hrs with specific β-Actin and Na+-K+-ATPase-targeted dsRNA demonstrated complete disruption of the specific gene transcript (Fig. 3A B).
