The aetiology of Sprengel's deformity is related to limb bud formation, which results in disruption of normal sequence of development during the foetal period [1, 2].
Use of electronic medical records was found to influence the way patient data were gathered, resulting in information loss and disruption of temporal sequence of events in assessing patient problem.
The event GRB 110328A (also denoted Swift J1644+57) was initially argued to be produced by the disruption of main sequence star by a black hole of several million times the mass of the Sun, although it has subsequently been argued that the disruption of a white dwarf by a black hole of mass about 10 thousand times the Sun may be more likely.
In plants, the GT splice donor site is present in almost all introns [19] and disruption of the sequence often leads to mis-splicing [20].
In addition to the disruption of genomic sequence through nucleases, CRISPR/Cas9 may be provided with effector domains that exert distinct regulatory functions.
Interestingly, while the human tetherin cytoplasmic tail has a putative TRAF6 consensus-binding motif (PXEXX-aromatic/acidic), disruption of this sequence by mutagenesis did not impair tetherin signaling.
Because the endpoints of the ARS1 S inversion do not include the sequences required for the initiation bias (described below), the reduction of the initiation bias can be attributed to the failure of the bias determinant to act on the ARS when the ARS is in inverted orientation and not to the disruption of the sequence causing the bias.
Disruption of this sequence of bases through a mutational effect can lead to altering the genetic code of certain amino acids.
CNVs are segments of DNA greater than 1 kb in size that can influence phenotypes by changing gene dosage and disruption of coding sequences in DNA.
This might be due to the hypomorphic nature of many P-element-associated mutations, or to the disruption of regulatory sequences of distant genes as opposed to proximal ones.
