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The discordance rate indicated the actual impact of disruption of recognition site.
Moreover, 57.1% of these under-called loci were due to the disruption of recognition site by SNPs incorporation mentioned above.
Individual MUP signatures can easily be identified regardless of other genetic variation between wild mice [12, 15], confirmed by the disruption of recognition when a recombinant MUP is added to wild mouse urine [12].
Given the general observation of OGlcNAcylation and phosphorylation in transcriptional regulatory elements and the broad importance of α-helical recognition epitopes in transcription, these data suggest the possibility of direct structural effects of both post-translational modifications on transcription, via both induction and disruption of recognition α-helices.
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By contrast, models assuming underspecification of redundant phonological information in the mental lexicon predict a differential disruption of word recognition dependent on the phonological structure of the pseudoword.
Mutational disruption of this recognition in cells affects pATM recruitment into foci in G1 and results in a defect in repair of DNA damage in heterochromatin.
Finally, mutations on ORC1 (P312S), CDC23 (P583T), and NUMA1 (P113H) illustrate how disruption of pleiotropic recognition motifs, such as the one for CDK1 kinase, can lead to upstream rewiring events.
In vitro study showed that disruption of exon 9 recognition from its 3' splice site by Fox and ESRP through UGCAUG and ISE/ISS-3 promoted switching to exon 8. Remaining question is whether the expression of Fox and ESRP coincides with the expression of exon 8 form in tissue-specific manner during development in vivo.
Mutant clone screening was in this case performed based on potential disruption of a restriction enzyme recognition site within the TALEN targeting region.
One such oncomiR, miR-155, represses murine AID, and the disruption of the miR-155 recognition site or miR-155 itself results in increased AID-induced c-MYC translocation [ 29] and BCL6 mutagenesis [ 30].
Family physicians were compensated $200 CDN as a token of recognition for the disruption to their work.
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