As reviewed here, dysfunction and/or disruption of nodes play significant roles in the development of neurological symptoms.
Disruption of apoptosis plays a major role in tumor formation and malignant progression.
Disruption of apoptosis plays a major role in tumor formation and malignant progression (Lowe and Lin 2000).
The missing link between peripheral and CNS inflammation, that is, the disruption of BBB, may play a vital role in the development of schizophrenia [23] and bipolar disorder [24].
These findings suggest that the disruption of immune response play a role in the pathogenesis of osteonecrosis.
In Drosophila, disruption of proteins that play a role in mitochondria quality control, PINK1 and parkin, results in similar mitochondrial morphological defects, including swollen mitochondria, fragmented cristae structure and matrix degeneration (Park et al., 2006; Saini et al., 2011; Klein et al., 2014).
He said the position appealed to him as a way to give back to the institute, which has supported his research since 1987, and also as a way to make a contribution to science beyond his own research, which examines how genes are turned on and off and how the disruption of that process plays out in diseases like cancer, diabetes and Huntington's.
He assumed this at a very challenging time for the club when we had lost a number of world-class players who had either retired or had left the club and at a time when we had the disruption of a year playing at Widnes and then a move to a new home in St Helens.
CONCLUSIONS: We conclude that disruption of CIITA function plays a beneficial role in preventing normal allogeneic T-cell responses.
Our findings suggest that a disruption of redox circuitry plays an important role in this specific chemical induction protocol, which might result in cytoskeletal alterations and loss of functional ion-gated channels followed by cell death.
