From these data, increasing pHi in the developing eye causes profound defects in tissue architecture that affect all cell types in the developing Drosophila eye, and shows severe disruption of patterning throughout this complex, multilayered epithelium.
It will be important in future studies to determine whether such a disruption of normal colonization patterns in smokers contributes to infectious complications and/or more efficient pathogen colonization.
However, the type 1 DM group receiving insulin showed a significantly decreased level and disruption of normal homogenous patterns of staining in cell bodies.
Individuals generally self-report increased effectiveness of sleep, so it is unlikely that the vivid dreams represent an adverse disruption of normal sleep patterns.
We proposed that the correlated expression pattern of these PcGs in normal gastric tissues might be necessary for maintenance of their normal functions, and disruption of the pattern might result in abnormal repression of their target genes.
We hypothesized that DEP exposure can lead to disruption of normal miRNA expression patterns, representing a plausible novel mechanism through which DEP can mediate disease initiation.
As such, the disruption of normal miR expression patterns could be a potential risk factor in neurodevelopmental disease, contributing to the sex-biases found in these disorders.
Mutants showed sequential super-stereotypy in the sense of having more stereotyped and predictable syntactic grooming sequences, and were also more likely to resist disruption of the pattern en route, by returning after a disruption to complete the pattern from the appropriate point in the sequence.
In other words, mutant mice were better than wild-type mice at resisting disruption of the pattern by minor flaws that occurred along the way, and mutants more often returned to the full-blown pattern after any distraction.
Disruption of this pattern and development of a warm and wet climate in eastern China occurred around the Oligocene/Miocene boundary at ca. 23 Ma (Sun and Wang 2005; Guo et al. 2008).
