There have been numerous mechanisms proposed for Al toxicity, but it is likely from the disruption of a number of different processes.
Thus disruption of a number of critical converging pathways including MAPK, PTEN, mTOR and FMRP appears important in neurodevelopmental conditions, either as a consequence of genetic or environmental risk factors during prenatal life [58].
Effects on memory are well documented, but lesions also result in increased activity, reduced anxiety, and disruption of a number of species-typical behaviors (Deacon et al., 2002).
After this procedure broken cells showed clear evidence of release of cytosol, as determined by discernible reduction of granularity and electron density (although residual cytoskeletal components were observed) and swelling and disruption of a number of organelles.
The outcome of EGFR targeting is characterised by the disruption of a number of cellular processes that mirror the physiological consequences of EGFR signal transduction at the level of cell division, apoptosis and angiogenesis (Castillo et al, 2004).
Once a bisphosphonate is taken up by an osteoclast, it causes the disruption of a number of biochemical processes involved in osteoclast function, typically resulting in apoptosis of the cell.
Although the roles of both classes and different paralogs are not yet totally elucidated and partially overlapping [ 31], the disruption of a number of hydrophobins resulted in altered hydrophobicity of the mycelia as well as the morphology and production of conidia [ 33– 33].
In the scale-free molecular network, targeted disruption of limited numbers of critical components designated hubs, on which the biologically important molecular interactions concentrate, efficiently disturbs the whole cellular function by destabilizing the network [ 9].
To further investigate a possible regulatory role of uNK or other lymphoid cells on macrophages, we also assessed the phenotype of myeloid cells in Rag2−/−γc−/− mice which showed neither disruption of macrophage numbers nor reduction in DC or monocytes despite the total absence of NK cells.
On the other side of the ledger, claims that the metadata program led to the disruption of a significant number of terrorist attacks seem to have been greatly exaggerated.
Disruption of a large number of cellular assemblies and processes, an increased protein unfolding and aggregation, and membrane structure alterations are paramount in cells exposed to high temperature.
