Sentence examples for disruption of key from inspiring English sources

The increasingly popular idea that cancers originate from disrupted or 'cancer-primed' progenitor cells is supported by the hypothesis that epigenetic disruption of key genes occurs at the earliest stage of cancer development (Feinberg et al, 2006).

The subsequent severe energy shortage combined with the disruption of key trade routes due to civil unrest in Georgia caused a sharp drop in industrial production, further devastating the economy.

The detrimental effects of antimicrobials include the disruption of key microbial processes in soil, toxicity to organisms, and the development of microbial resistance [107] [110].

The disruption of key interactions between IN and direct cellular cofactors affords a novel therapeutic approach for the design and development of new classes of anti-retroviral agents.

The researchers say the new type of imaging - which tracks the movement of water in the brain - will enable them to explore how the disruption of key processes might cause conditions such as autism.

The determinants of binding and specificity were distributed among contact and non-contact residues in germline and hypervariable loops, and included disruption of key TCR-MHC interactions that bias αβ TCRs toward particular binding modes.

From these simulations, it was concluded that various substitutions at the nonreducing end of the LacNAc core were tolerated with little or no disruption of key-binding interactions.

Remarkably, significant gene misexpression in backcross hybrids involved several genes, most notably the disruption of three key developmental genes involved in protein folding and mRNA translation.

Disruption of a key residue in the catalytic domain abolished both the in vitro activity and its ability to rescue the DR phenotype.

Disruption of these key regulators of early events in mitosis may contribute to the spindle abnormalities, failed centrosomal separation and prometaphase/prophase arrest that we observed in curcumin-treated mitotic cells.

6 64 65 Recently, it has been proposed that this higher endotoxaemia in ob/ob mice and db/db mice was dependent on a disruption of the key tight-junction proteins, ZO-1 and occludin.