Sentence examples for disruption of interactions from inspiring English sources
Disruption of interactions made by the N-terminal region results in spontaneous conformational change of this serpin to the latent conformation.
However, in some instances (but not many), trapping complexes by the folded PCA reporter protein could prevent detection, particularly of disruption of interactions.
A possible consequence might have been a general effect on process outgrowth via disruption of interactions between gMSD-associated signaling molecules and downstream effectors that mediate changes in cytoskeletal organization or attachment to cytoskeletal elements.
However, several theoretical models have been proposed for testing the underlying mechanisms such as haploinsufficiency, splicing rate-limitation and disruption of interactions of splicing factors with photoreceptor-specific cofactor(s).
Nevertheless, the cancer-associated genome hypomethylation could be explained by the disruption of interactions existing between Dnmts and the DNA replication and DNA repair proteins because these interactions play a crucial role in the DNA methylation in mammalian cells [6], [7], [8].
Literature reporting that PCNA and UHRF1 proteins mediate the epigenetic inheritance in mammalian cells by recruiting Dnmt1, we then hypothesized that the defect of Dnmt1 recruitment on DNA could be due to the disruption of interactions existing between Dnmt1, PCNA and UHRF1 [8], [8].
The suppression of the detachment-induced cell death (anoikis) by the interaction between the cells and extracellular matrix (ECM) is necessary for the application of liver tissue engineering because the disruption of interaction with ECM leads hepatocytes to anoikis.
Dysregulation of the OGF-OGFr pathway is apparent in a number of human disorders including diabetes, multiple sclerosis, and cancer, and thus opioid antagonist disruption of interaction prevails as a therapeutic intervention.
Previously, we have shown that disruption of interaction between ΔF508-CFTR and keratin 8 leads to restoration functional ΔF508-CFTR.
We have shown in a previous study that disruption of interaction between the intermediate filament protein keratin 8 and ΔF508-CFTR leads to functional correction of the mutated protein (Colas et al, 2012).
