Sentence examples for disruption of interaction from inspiring English sources
The suppression of the detachment-induced cell death (anoikis) by the interaction between the cells and extracellular matrix (ECM) is necessary for the application of liver tissue engineering because the disruption of interaction with ECM leads hepatocytes to anoikis.
Dysregulation of the OGF-OGFr pathway is apparent in a number of human disorders including diabetes, multiple sclerosis, and cancer, and thus opioid antagonist disruption of interaction prevails as a therapeutic intervention.
However, Akt inhibition may take place in a SIRT1 –independent way [35], [36] through disruption of interaction between upstream signaling elements such as PI3 Kinase or Grb2 (growth factor receptor-bound protein 2) with further upstream proteins relaying signals directly from the receptor [36].
In the previous prediction, the extending from B- to E-EGF orientation induced directly the allostery of Lec domain from S1 to S2 via sequential interactions along the following pathway: First, the extending orientation broke up the interaction network near H region between EGF and Lec domains, followed by the disruption of interaction among residues W1, A28, and E34 via a water molecule.
AcCoA makes additional binding interactions with the enzyme such that disruption of interaction with Q84 is well tolerated.
Previously, we have shown that disruption of interaction between ΔF508-CFTR and keratin 8 leads to restoration functional ΔF508-CFTR.
The data and analyses described here provide novel insights into two putative mechanisms: the disruption of interactions between PFN1 and actin- or PLP-binding motifs.
Disruption of interactions made by the N-terminal region results in spontaneous conformational change of this serpin to the latent conformation.
However, in some instances (but not many), trapping complexes by the folded PCA reporter protein could prevent detection, particularly of disruption of interactions.
However, several theoretical models have been proposed for testing the underlying mechanisms such as haploinsufficiency, splicing rate-limitation and disruption of interactions of splicing factors with photoreceptor-specific cofactor(s).
A possible consequence might have been a general effect on process outgrowth via disruption of interactions between gMSD-associated signaling molecules and downstream effectors that mediate changes in cytoskeletal organization or attachment to cytoskeletal elements.
