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From the earliest days of nineteenth-century aphasiology, language deficits due to focal brain lesions have been attributed to two basic mechanisms: local cortical dysfunction at the lesion site, and remote cortical dysfunction due to disruption of information transfer along pathways between connected brain regions (Wernicke, 1874; Geschwind, 1965 a, b ).
Because the model predicts that the subthalamic nucleus is involved in updating probabilities on the basis of combined pieces of information, we hypothesized that disruption of information processing in the subthalamic nucleus owing to DBS should impair patients' ability to combine probabilistic information.
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A detailed analysis of the topology of the PGP network has allowed us to conclude that coordination failures arise from certain mesoscopic structures, more concretely from bottlenecks or topological traps that prevent the Pareto-efficient equilibrium from propagating to the whole network, effectively leading to a disruption of the information flow.
These results demonstrate that the poor performance on egocentric incongruent trials reflects the specific disruption of egocentric information.
The probe test in Experiment 2 provided evidence that this effect was primarily due to disruption of egocentric spatial information rather than allocentric information (Fig. 7).
The fact that the congruency of allocentric information had opposite effects in the trials starting from the different start arms suggests that mice were not impaired on the allocentric + egocentric incongruent trials due to disruption of the allocentric information, but due to the disruption of the egocentric information.
Therefore, a company may incur loss due to disruptions and unavailability of information systems.
The repression of the TCP target genes was largely relieved by the disruption of TPL/TPRs (Supplementary information, Figure S5A).
"The gloves are coming off as the tools of cybercrime are merging with the tools of information disruption.
We also made sure that the medically qualified investigators acted as a buffer between the field workers and community power-groups to minimize disruption and ensure confidentiality of information.
Specifically, we hypothesized that genomic (and epigenomic) alterations would lead to disruptions in the dynamics of information flow on protein interaction networks, and that this disruption would manifest itself as a higher degree of randomness in the patterns of local gene expression correlations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com